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BDBM185681 UNC10107955::US9156822, 11

SMILES: COc1ccccc1N1CCCN(CCCCOc2ccc3CCC(=O)Nc3n2)CC1

InChI Key: InChIKey=GWOIEWDIINTVPJ-UHFFFAOYSA-N

Data: 1 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 185681   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM185681
PNG
(UNC10107955 | US9156822, 11)
Show SMILES COc1ccccc1N1CCCN(CCCCOc2ccc3CCC(=O)Nc3n2)CC1
Show InChI InChI=1S/C24H32N4O3/c1-30-21-8-3-2-7-20(21)28-15-6-14-27(16-17-28)13-4-5-18-31-23-12-10-19-9-11-22(29)25-24(19)26-23/h2-3,7-8,10,12H,4-6,9,11,13-18H2,1H3,(H,25,26,29)
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KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.70n/an/an/an/an/an/a7.4n/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well...


US Patent US9156822 (2015)


BindingDB Entry DOI: 10.7270/Q2H41Q6D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM185681
PNG
(UNC10107955 | US9156822, 11)
Show SMILES COc1ccccc1N1CCCN(CCCCOc2ccc3CCC(=O)Nc3n2)CC1
Show InChI InChI=1S/C24H32N4O3/c1-30-21-8-3-2-7-20(21)28-15-6-14-27(16-17-28)13-4-5-18-31-23-12-10-19-9-11-22(29)25-24(19)26-23/h2-3,7-8,10,12H,4-6,9,11,13-18H2,1H3,(H,25,26,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6.10n/an/a7.4n/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Recruitment of β-arrestin to agonist-stimulated D2 receptors was performed using a previously described Tango-type assay (Barnea et al., Proc. N...


US Patent US9156822 (2015)


BindingDB Entry DOI: 10.7270/Q2H41Q6D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM185681
PNG
(UNC10107955 | US9156822, 11)
Show SMILES COc1ccccc1N1CCCN(CCCCOc2ccc3CCC(=O)Nc3n2)CC1
Show InChI InChI=1S/C24H32N4O3/c1-30-21-8-3-2-7-20(21)28-15-6-14-27(16-17-28)13-4-5-18-31-23-12-10-19-9-11-22(29)25-24(19)26-23/h2-3,7-8,10,12H,4-6,9,11,13-18H2,1H3,(H,25,26,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 222n/an/a7.4n/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
HEK293T cells co-expressing the cAMP biosensor GloSensor-22F (Promega) and hD2 receptors were seeded (10,000 cells/20 ul/well) into white, clear-bott...


US Patent US9156822 (2015)


BindingDB Entry DOI: 10.7270/Q2H41Q6D
More data for this
Ligand-Target Pair