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BDBM185683 UNC10107959::US9156822, 13

SMILES: CCOc1ccccc1N1CCCN(CCCCOc2ccc3CCC(=O)Nc3n2)CC1

InChI Key: InChIKey=LVVVBEVBRWMYII-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 185683   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM185683
PNG
(UNC10107959 | US9156822, 13)
Show SMILES CCOc1ccccc1N1CCCN(CCCCOc2ccc3CCC(=O)Nc3n2)CC1
Show InChI InChI=1S/C25H34N4O3/c1-2-31-22-9-4-3-8-21(22)29-16-7-15-28(17-18-29)14-5-6-19-32-24-13-11-20-10-12-23(30)26-25(20)27-24/h3-4,8-9,11,13H,2,5-7,10,12,14-19H2,1H3,(H,26,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
4.40n/an/an/an/an/an/a7.4n/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well...


US Patent US9156822 (2015)


BindingDB Entry DOI: 10.7270/Q2H41Q6D
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM185683
PNG
(UNC10107959 | US9156822, 13)
Show SMILES CCOc1ccccc1N1CCCN(CCCCOc2ccc3CCC(=O)Nc3n2)CC1
Show InChI InChI=1S/C25H34N4O3/c1-2-31-22-9-4-3-8-21(22)29-16-7-15-28(17-18-29)14-5-6-19-32-24-13-11-20-10-12-23(30)26-25(20)27-24/h3-4,8-9,11,13H,2,5-7,10,12,14-19H2,1H3,(H,26,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4n/an/a7.4n/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Recruitment of β-arrestin to agonist-stimulated D2 receptors was performed using a previously described Tango-type assay (Barnea et al., Proc. N...


US Patent US9156822 (2015)


BindingDB Entry DOI: 10.7270/Q2H41Q6D
More data for this
Ligand-Target Pair