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BDBM186567 US9163021, 235

SMILES: CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cnccc12

InChI Key: InChIKey=WYAROKBDTRGMID-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186567   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM186567
PNG
(US9163021, 235)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C26H23F3N4O3/c1-25(2,15-34)33-14-21(20-13-30-7-6-22(20)33)24(36)17-10-19(12-31-11-17)32-23(35)9-16-4-3-5-18(8-16)26(27,28)29/h3-8,10-14,34H,9,15H2,1-2H3,(H,32,35)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.87n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...


US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair