null

SMILES: FC(F)(F)c1ccnc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1

InChI Key: InChIKey=OQLJNDMHGLMPJJ-ACRUOGEOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 186810   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] (Homo sapiens (Human))	BDBM186810 (US9670203, Compound 1.2) Show SMILES FC(F)(F)c1ccnc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1 |r| Show InChI InChI=1S/C24H18F3N5O4/c25-24(26,27)11-5-7-28-17(9-11)30-23(34)32-20-19-14-10-12(1-3-15(14)36-21(19)20)35-16-6-8-29-22-13(16)2-4-18(33)31-22/h1,3,5-10,19-21H,2,4H2,(H,29,31,33)(H2,28,30,32,34)/t19-,20-,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human))	BDBM186810 (US9670203, Compound 1.2) Show SMILES FC(F)(F)c1ccnc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1 |r| Show InChI InChI=1S/C24H18F3N5O4/c25-24(26,27)11-5-7-28-17(9-11)30-23(34)32-20-19-14-10-12(1-3-15(14)36-21(19)20)35-16-6-8-29-22-13(16)2-4-18(33)31-22/h1,3,5-10,19-21H,2,4H2,(H,29,31,33)(H2,28,30,32,34)/t19-,20-,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair