null

SMILES: COc1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1Cl

InChI Key: InChIKey=RAZJJMAZDRQDPE-PMVMPFDFSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 186814   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] (Homo sapiens (Human))	BDBM186814 (US9670203, Compound 1.6) Show SMILES COc1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1Cl |r| Show InChI InChI=1S/C25H21ClN4O5/c1-33-18-4-2-3-15(21(18)26)28-25(32)30-22-20-14-11-12(5-7-16(14)35-23(20)22)34-17-9-10-27-24-13(17)6-8-19(31)29-24/h2-5,7,9-11,20,22-23H,6,8H2,1H3,(H,27,29,31)(H2,28,30,32)/t20-,22-,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human))	BDBM186814 (US9670203, Compound 1.6) Show SMILES COc1cccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1Cl |r| Show InChI InChI=1S/C25H21ClN4O5/c1-33-18-4-2-3-15(21(18)26)28-25(32)30-22-20-14-11-12(5-7-16(14)35-23(20)22)34-17-9-10-27-24-13(17)6-8-19(31)29-24/h2-5,7,9-11,20,22-23H,6,8H2,1H3,(H,27,29,31)(H2,28,30,32)/t20-,22-,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair