BDBM186817 US9670203, Compound 1.9

SMILES: FC(F)(F)c1cc(Cl)ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12

InChI Key: InChIKey=NMXIZHLCNCWEPN-FKBYEOEOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 186817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] (Homo sapiens (Human))	BDBM186817 (US9670203, Compound 1.9) Show SMILES FC(F)(F)c1cc(Cl)ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C25H18ClF3N4O4/c26-11-1-4-16(15(9-11)25(27,28)29)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human))	BDBM186817 (US9670203, Compound 1.9) Show SMILES FC(F)(F)c1cc(Cl)ccc1NC(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C25H18ClF3N4O4/c26-11-1-4-16(15(9-11)25(27,28)29)31-24(35)33-21-20-14-10-12(2-5-17(14)37-22(20)21)36-18-7-8-30-23-13(18)3-6-19(34)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,32,34)(H2,31,33,35)/t20-,21-,22-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair