BDBM186820 US9670203, Compound 1.12

SMILES: Fc1c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cccc1C(F)(F)F

InChI Key: InChIKey=ZTLFXSAPVHEPGO-BVSLBCMMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 186820   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-Raf (Y340D/Y341D) (Homo sapiens (Human))	BDBM186820 (US9670203, Compound 1.12) Show SMILES Fc1c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cccc1C(F)(F)F |r| Show InChI InChI=1S/C25H18F4N4O4/c26-20-14(25(27,28)29)2-1-3-15(20)31-24(35)33-21-19-13-10-11(4-6-16(13)37-22(19)21)36-17-8-9-30-23-12(17)5-7-18(34)32-23/h1-4,6,8-10,19,21-22H,5,7H2,(H,30,32,34)(H2,31,33,35)/t19-,21-,22-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair
B-Raf (V600E) (Homo sapiens (Human))	BDBM186820 (US9670203, Compound 1.12) Show SMILES Fc1c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cccc1C(F)(F)F |r| Show InChI InChI=1S/C25H18F4N4O4/c26-20-14(25(27,28)29)2-1-3-15(20)31-24(35)33-21-19-13-10-11(4-6-16(13)37-22(19)21)36-17-8-9-30-23-12(17)5-7-18(34)32-23/h1-4,6,8-10,19,21-22H,5,7H2,(H,30,32,34)(H2,31,33,35)/t19-,21-,22-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair