BDBM186981 US9169209, Table 3, Compound 12

SMILES: O=C(Nc1ccc(cc1)S(=O)(=O)c1cncc(c1)N1CCCC1)\C=C\c1cccnc1

InChI Key: InChIKey=LCQIWXYMSHHYEZ-BJMVGYQFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186981   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM186981 (US9169209, Table 3, Compound 12) Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cncc(c1)N1CCCC1)\C=C\c1cccnc1 Show InChI InChI=1S/C23H22N4O3S/c28-23(10-5-18-4-3-11-24-15-18)26-19-6-8-21(9-7-19)31(29,30)22-14-20(16-25-17-22)27-12-1-2-13-27/h3-11,14-17H,1-2,12-13H2,(H,26,28)/b10-5+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9169209 (2015) BindingDB Entry DOI: 10.7270/Q28G8JH9
					More data for this Ligand-Target Pair