BDBM187124 US9670161, 5 N-{6-(Difluoromethyl)-4-[(methylsulfonyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine
SMILES: COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)cc(n2)C(F)F)ncc1F
InChI Key: InChIKey=DXLAOXPSVTUHAP-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-Dependent Kinase 9 (CDK9) (Homo sapiens (Human)) | BDBM187124 (US9670161, 5 N-{6-(Difluoromethyl)-4-[(methylsulfo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 8.0 | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description Recombinant full-length His-tagged human CDK9 and CycT1, expressed in insect cells and purified by Ni-NTA affinity chromatography, were purchased fro... | US Patent US9670161 (2017) BindingDB Entry DOI: 10.7270/Q29G5K05 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM187124 (US9670161, 5 N-{6-(Difluoromethyl)-4-[(methylsulfo...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 103 | n/a | n/a | n/a | n/a | 8.0 | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sepharose aff... | US Patent US9670161 (2017) BindingDB Entry DOI: 10.7270/Q29G5K05 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 9 (CDK9) (Homo sapiens (Human)) | BDBM187124 (US9670161, 5 N-{6-(Difluoromethyl)-4-[(methylsulfo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 8.0 | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description Recombinant full-length His-tagged human CDK9 and CycT1, expressed in insect cells and purified by Ni-NTA affinity chromatography, were purchase from... | US Patent US9670161 (2017) BindingDB Entry DOI: 10.7270/Q29G5K05 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM187124 (US9670161, 5 N-{6-(Difluoromethyl)-4-[(methylsulfo...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 8.0 | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sepharose aff... | US Patent US9670161 (2017) BindingDB Entry DOI: 10.7270/Q29G5K05 | |||||||||||
More data for this Ligand-Target Pair |