BDBM187155 US9670181, 35 4-((2-(ethylamino)-6-methylquinolin-3-yl)methyl)-6,7-dimethoxy-1-propylisoquinolin-3-

SMILES: CCCc1nc(O)c(Cc2cc3cc(C)ccc3nc2NCC)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=WICRNTXCQOTVKW-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187155   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187155 (US9670181, 35 4-((2-(ethylamino)-6-methylquinolin-...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(C)ccc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H31N3O3/c1-6-8-23-20-15-25(33-5)24(32-4)14-19(20)21(27(31)30-23)13-18-12-17-11-16(3)9-10-22(17)29-26(18)28-7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
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