BDBM187160 US9670181, 40 1-ethyl-4-((2-(ethylamino)-6-methoxyquinolin-3-yl)methyl)-6,7-dimethoxyisoquinolin-3-ol

SMILES: CCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(CC)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=OZPXYKLNWTVVJQ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187160   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187160 (US9670181, 40 1-ethyl-4-((2-(ethylamino)-6-methoxy...) Show SMILES CCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(CC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H29N3O4/c1-6-21-19-14-24(33-5)23(32-4)13-18(19)20(26(30)29-21)12-16-10-15-11-17(31-3)8-9-22(15)28-25(16)27-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,27,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair