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SMILES: CCCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(CCC)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=PLYWPPNPPNLKNV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187173   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM187173
PNG
(US9670181, 52 6,7-dimethoxy-4-((6-methoxy-2-(propy...)
Show SMILES CCCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(CCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C28H33N3O4/c1-6-8-24-21-16-26(35-5)25(34-4)15-20(21)22(28(32)31-24)14-18-12-17-13-19(33-3)9-10-23(17)30-27(18)29-11-7-2/h9-10,12-13,15-16H,6-8,11,14H2,1-5H3,(H,29,30)(H,31,32)
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US Patent
n/an/a 1.5n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...

US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair