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SMILES: CCCc1nc(O)c(Cc2cc3cc4OCOc4cc3nc2NCC)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=YKXBEBYXGCQYRD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187186   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM187186
PNG
(US9670181, 64 4-((6-(ethylamino)-[1,3]dioxolo[4,5-...)
Show SMILES CCCc1nc(O)c(Cc2cc3cc4OCOc4cc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H29N3O5/c1-5-7-20-18-12-23(33-4)22(32-3)11-17(18)19(27(31)30-20)9-16-8-15-10-24-25(35-14-34-24)13-21(15)29-26(16)28-6-2/h8,10-13H,5-7,9,14H2,1-4H3,(H,28,29)(H,30,31)
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PC cid
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US Patent
n/an/a 1.20n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...

US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair