BDBM187210 US9670181, 86 4-((6-ethoxy-2-(ethylamino)-7-fluoroquinolin-3-yl)methyl)-6,7-dimethoxy-1-propylisoquinolin-3-ol

SMILES: CCCc1nc(O)c(Cc2cc3cc(OCC)c(F)cc3nc2NCC)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=PEWDNQHXCRPIFW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187210   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187210 (US9670181, 86 4-((6-ethoxy-2-(ethylamino)-7-fluoro...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OCC)c(F)cc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C28H32FN3O4/c1-6-9-22-19-14-26(35-5)25(34-4)13-18(19)20(28(33)32-22)11-17-10-16-12-24(36-8-3)21(29)15-23(16)31-27(17)30-7-2/h10,12-15H,6-9,11H2,1-5H3,(H,30,31)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair