BDBM187423 US9169252, 24::US9169252, 25::US9169252, 26::US9169252, 27

SMILES: CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CCC(O)C1)-n1ccc2cc(cnc12)C#N

InChI Key: InChIKey=FVDCNCNSRJWBDU-LBXVMSDZSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 187423   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM187423 (US9169252, 24 | US9169252, 25 | US9169252, 26 | US...) Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CCC(O)C1)-n1ccc2cc(cnc12)C#N |r| Show InChI InChI=1S/C24H27FN6O3/c1-24(2,34)20(25)13-29-23(33)18-12-27-21(9-19(18)30-16-3-4-17(32)8-16)31-6-5-15-7-14(10-26)11-28-22(15)31/h5-7,9,11-12,16-17,20,32,34H,3-4,8,13H2,1-2H3,(H,27,30)(H,29,33)/t16?,17?,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.2	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...				US Patent US9169252 (2015) BindingDB Entry DOI: 10.7270/Q2MP5235
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM187423 (US9169252, 24 | US9169252, 25 | US9169252, 26 | US...) Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CCC(O)C1)-n1ccc2cc(cnc12)C#N |r| Show InChI InChI=1S/C24H27FN6O3/c1-24(2,34)20(25)13-29-23(33)18-12-27-21(9-19(18)30-16-3-4-17(32)8-16)31-6-5-15-7-14(10-26)11-28-22(15)31/h5-7,9,11-12,16-17,20,32,34H,3-4,8,13H2,1-2H3,(H,27,30)(H,29,33)/t16?,17?,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.2	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...				US Patent US9169252 (2015) BindingDB Entry DOI: 10.7270/Q2MP5235
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM187423 (US9169252, 24 | US9169252, 25 | US9169252, 26 | US...) Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CCC(O)C1)-n1ccc2cc(cnc12)C#N |r| Show InChI InChI=1S/C24H27FN6O3/c1-24(2,34)20(25)13-29-23(33)18-12-27-21(9-19(18)30-16-3-4-17(32)8-16)31-6-5-15-7-14(10-26)11-28-22(15)31/h5-7,9,11-12,16-17,20,32,34H,3-4,8,13H2,1-2H3,(H,27,30)(H,29,33)/t16?,17?,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.2	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...				US Patent US9169252 (2015) BindingDB Entry DOI: 10.7270/Q2MP5235
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM187423 (US9169252, 24 | US9169252, 25 | US9169252, 26 | US...) Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1NC1CCC(O)C1)-n1ccc2cc(cnc12)C#N |r| Show InChI InChI=1S/C24H27FN6O3/c1-24(2,34)20(25)13-29-23(33)18-12-27-21(9-19(18)30-16-3-4-17(32)8-16)31-6-5-15-7-14(10-26)11-28-22(15)31/h5-7,9,11-12,16-17,20,32,34H,3-4,8,13H2,1-2H3,(H,27,30)(H,29,33)/t16?,17?,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.2	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...				US Patent US9169252 (2015) BindingDB Entry DOI: 10.7270/Q2MP5235
					More data for this Ligand-Target Pair