BDBM187843 US9169252, 386

SMILES: CCNC(=O)n1cc(Nc2cc(ncc2C(=O)NC[C@@H](F)C(C)(C)O)-n2ncc3cc(cnc23)C#N)cn1

InChI Key: InChIKey=MNCRDFOGPJRZIT-LJQANCHMSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 187843   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM187843 (US9169252, 386) Show SMILES CCNC(=O)n1cc(Nc2cc(ncc2C(=O)NC[C@@H](F)C(C)(C)O)-n2ncc3cc(cnc23)C#N)cn1 |r| Show InChI InChI=1S/C24H25FN10O3/c1-4-27-23(37)34-13-16(10-31-34)33-18-6-20(35-21-15(9-32-35)5-14(7-26)8-29-21)28-11-17(18)22(36)30-12-19(25)24(2,3)38/h5-6,8-11,13,19,38H,4,12H2,1-3H3,(H,27,37)(H,28,33)(H,30,36)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.2	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...				US Patent US9169252 (2015) BindingDB Entry DOI: 10.7270/Q2MP5235
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