BDBM187893 US9169252, 434::US9169252, 442

SMILES: COC(C)(C)[C@H](F)CNC(=O)c1cnc(cc1NC(C)C)-n1ccc2cc(cnc12)C#N

InChI Key: InChIKey=DDJPRVYMXFFEIW-LJQANCHMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 187893   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM187893 (US9169252, 434 | US9169252, 442) Show SMILES COC(C)(C)[C@H](F)CNC(=O)c1cnc(cc1NC(C)C)-n1ccc2cc(cnc12)C#N |r| Show InChI InChI=1S/C23H27FN6O2/c1-14(2)29-18-9-20(30-7-6-16-8-15(10-25)11-27-21(16)30)26-12-17(18)22(31)28-13-19(24)23(3,4)32-5/h6-9,11-12,14,19H,13H2,1-5H3,(H,26,29)(H,28,31)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.2	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...				US Patent US9169252 (2015) BindingDB Entry DOI: 10.7270/Q2MP5235
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM187893 (US9169252, 434 | US9169252, 442) Show SMILES COC(C)(C)[C@H](F)CNC(=O)c1cnc(cc1NC(C)C)-n1ccc2cc(cnc12)C#N |r| Show InChI InChI=1S/C23H27FN6O2/c1-14(2)29-18-9-20(30-7-6-16-8-15(10-25)11-27-21(16)30)26-12-17(18)22(31)28-13-19(24)23(3,4)32-5/h6-9,11-12,14,19H,13H2,1-5H3,(H,26,29)(H,28,31)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.2	25
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 L prepared from 15 L additions of enzyme and substrates (fluores...				US Patent US9169252 (2015) BindingDB Entry DOI: 10.7270/Q2MP5235
					More data for this Ligand-Target Pair