BDBM188334 US9670203, Compound 1.40

SMILES: Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1

InChI Key: InChIKey=ZPTOWZAHHCIDOJ-BVSLBCMMSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 188334   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] (Homo sapiens (Human))	BDBM188334 (US9670203, Compound 1.40) Show SMILES Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1 |r| Show InChI InChI=1S/C24H17F3N4O4/c25-10-7-14(26)20(15(27)8-10)30-24(33)31-21-19-13-9-11(1-3-16(13)35-22(19)21)34-17-5-6-28-23-12(17)2-4-18(32)29-23/h1,3,5-9,19,21-22H,2,4H2,(H,28,29,32)(H2,30,31,33)/t19-,21-,22-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human))	BDBM188334 (US9670203, Compound 1.40) Show SMILES Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1 |r| Show InChI InChI=1S/C24H17F3N4O4/c25-10-7-14(26)20(15(27)8-10)30-24(33)31-21-19-13-9-11(1-3-16(13)35-22(19)21)34-17-5-6-28-23-12(17)2-4-18(32)29-23/h1,3,5-9,19,21-22H,2,4H2,(H,28,29,32)(H2,30,31,33)/t19-,21-,22-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair