BDBM189302 US9670203, Compound 1.46

SMILES: Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1F

InChI Key: InChIKey=UVFPAUPHTITLLA-NYVOZVTQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 189302   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] (Homo sapiens (Human))	BDBM189302 (US9670203, Compound 1.46) Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1F |r| Show InChI InChI=1S/C24H17F3N4O4/c25-13-3-4-14(20(27)19(13)26)29-24(33)31-21-18-12-9-10(1-5-15(12)35-22(18)21)34-16-7-8-28-23-11(16)2-6-17(32)30-23/h1,3-5,7-9,18,21-22H,2,6H2,(H,28,30,32)(H2,29,31,33)/t18-,21-,22-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human))	BDBM189302 (US9670203, Compound 1.46) Show SMILES Fc1ccc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c(F)c1F |r| Show InChI InChI=1S/C24H17F3N4O4/c25-13-3-4-14(20(27)19(13)26)29-24(33)31-21-18-12-9-10(1-5-15(12)35-22(18)21)34-16-7-8-28-23-11(16)2-6-17(32)30-23/h1,3-5,7-9,18,21-22H,2,6H2,(H,28,30,32)(H2,29,31,33)/t18-,21-,22-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair