null

SMILES: CCOC(=O)C(=O)CC(=O)\C=C\c1cccn1Cc1ccccc1Cl

InChI Key: InChIKey=BPIOFONJRYTCQB-MDZDMXLPSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 189342   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189342 (RDS1759) Show SMILES CCOC(=O)C(=O)CC(=O)\C=C\c1cccn1Cc1ccccc1Cl Show InChI InChI=1S/C19H18ClNO4/c1-2-25-19(24)18(23)12-16(22)10-9-15-7-5-11-21(15)13-14-6-3-4-8-17(14)20/h3-11H,2,12-13H2,1H3/b10-9+	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	7.8	37
University of Siena					Assay Description HIV RT-associated RNase H activity was measured as previously described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction mixture comprised ...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189342 (RDS1759) Show SMILES CCOC(=O)C(=O)CC(=O)\C=C\c1cccn1Cc1ccccc1Cl Show InChI InChI=1S/C19H18ClNO4/c1-2-25-19(24)18(23)12-16(22)10-9-15-7-5-11-21(15)13-14-6-3-4-8-17(14)20/h3-11H,2,12-13H2,1H3/b10-9+	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	7.8	n/a
University of Siena					Assay Description The RNase H activity associated with HIV-1 RT was measured in a 100 mL reactionvolume containing Tris·HCl (pH 7.8, 50 mm), MgCl2 (6 mm), dithiothreit...				Chembiochem 18: 374-377 (2017) Article DOI: 10.1002/cbic.201600592 BindingDB Entry DOI: 10.7270/Q2N29VS8
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189342 (RDS1759) Show SMILES CCOC(=O)C(=O)CC(=O)\C=C\c1cccn1Cc1ccccc1Cl Show InChI InChI=1S/C19H18ClNO4/c1-2-25-19(24)18(23)12-16(22)10-9-15-7-5-11-21(15)13-14-6-3-4-8-17(14)20/h3-11H,2,12-13H2,1H3/b10-9+	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	8.1	n/a
University of Siena					Assay Description The RNA-dependent DNA polymerase (RDDP) activity associated with HIV-1 RT was measured by use of the Invitrogen EnzCheck Reverse Transcriptase Assay ...				Chembiochem 18: 374-377 (2017) Article DOI: 10.1002/cbic.201600592 BindingDB Entry DOI: 10.7270/Q2N29VS8
					More data for this Ligand-Target Pair