BDBM189361 SRI35564

SMILES: Cc1ccc(cc1)C1C(C#N)=C(N)Nc2ncnn12

InChI Key: InChIKey=YISIIJDKYGEHIN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189361   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitotic kinesin Eg5 (Eg5) (Homo sapiens (Human))	BDBM189361 (SRI35564) Show SMILES Cc1ccc(cc1)C1C(C#N)=C(N)Nc2ncnn12 |t:11| Show InChI InChI=1S/C13H12N6/c1-8-2-4-9(5-3-8)11-10(6-14)12(15)18-13-16-7-17-19(11)13/h2-5,7,11H,15H2,1H3,(H,16,17,18)	PDB GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.18E+5	n/a	n/a	n/a	n/a	7.0	25
Southern Research Institute					Assay Description Compounds were first tested in triplicates at 100 uM; hit compounds were further tested with a 10-point twofold serial dilution to confirm their acti...				Chem Biol Drug Des 88: 178-87 (2016) Article DOI: 10.1111/cbdd.12744 BindingDB Entry DOI: 10.7270/Q2NK3CV8
					More data for this Ligand-Target Pair