null

SMILES: CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(N[C@@H]4CCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1

InChI Key: InChIKey=LTQSONOIEBRYPY-JGCGQSQUSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 189669   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189669 (US10213433, Compound 238 | US11369599, Compound 23...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(N[C@@H]4CCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:55| Show InChI InChI=1S/C43H46ClN7O7S/c1-43(2)14-11-30(37(24-43)28-3-5-31(44)6-4-28)26-49-16-18-50(19-17-49)33-7-9-36(40(22-33)58-34-21-29-12-15-45-41(29)46-25-34)42(52)48-59(55,56)35-8-10-38(39(23-35)51(53)54)47-32-13-20-57-27-32/h3-10,12,15,21-23,25,32,47H,11,13-14,16-20,24,26-27H2,1-2H3,(H,45,46)(H,48,52)/t32-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	<-15.0	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC.; GENENTECH, INC.; THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH US Patent					Assay Description Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...				US Patent US9174982 (2015) BindingDB Entry DOI: 10.7270/Q2RB73D5
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189669 (US10213433, Compound 238 | US11369599, Compound 23...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(N[C@@H]4CCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:55| Show InChI InChI=1S/C43H46ClN7O7S/c1-43(2)14-11-30(37(24-43)28-3-5-31(44)6-4-28)26-49-16-18-50(19-17-49)33-7-9-36(40(22-33)58-34-21-29-12-15-45-41(29)46-25-34)42(52)48-59(55,56)35-8-10-38(39(23-35)51(53)54)47-32-13-20-57-27-32/h3-10,12,15,21-23,25,32,47H,11,13-14,16-20,24,26-27H2,1-2H3,(H,45,46)(H,48,52)/t32-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189669 (US10213433, Compound 238 | US11369599, Compound 23...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(N[C@@H]4CCOC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:55| Show InChI InChI=1S/C43H46ClN7O7S/c1-43(2)14-11-30(37(24-43)28-3-5-31(44)6-4-28)26-49-16-18-50(19-17-49)33-7-9-36(40(22-33)58-34-21-29-12-15-45-41(29)46-25-34)42(52)48-59(55,56)35-8-10-38(39(23-35)51(53)54)47-32-13-20-57-27-32/h3-10,12,15,21-23,25,32,47H,11,13-14,16-20,24,26-27H2,1-2H3,(H,45,46)(H,48,52)/t32-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.				US Patent US10213433 (2019) BindingDB Entry DOI: 10.7270/Q23F4RZ6
					More data for this Ligand-Target Pair