BDBM189671 US10213433, Compound 240::US9174982, 240

SMILES: CC(C)(C)N1CCC(CC1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(Cl)cc2)CC1

InChI Key: InChIKey=VOTPTOZQRWBMKX-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 189671   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189671 (US10213433, Compound 240 | US9174982, 240) Show SMILES CC(C)(C)N1CCC(CC1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(Cl)cc2)CC1 |t:56| Show InChI InChI=1S/C49H57ClF3N7O6S2/c1-47(2,3)60-20-16-36(17-21-60)56-42-13-11-39(28-44(42)67(62,63)49(51,52)53)68(64,65)57-46(61)40-12-10-37(27-43(40)66-38-26-33-15-19-54-45(33)55-30-38)59-24-22-58(23-25-59)31-34-14-18-48(4,5)29-41(34)32-6-8-35(50)9-7-32/h6-13,15,19,26-28,30,36,56H,14,16-18,20-25,29,31H2,1-5H3,(H,54,55)(H,57,61)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.				US Patent US10213433 (2019) BindingDB Entry DOI: 10.7270/Q23F4RZ6
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189671 (US10213433, Compound 240 | US9174982, 240) Show SMILES CC(C)(C)N1CCC(CC1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(Cl)cc2)CC1 |t:56| Show InChI InChI=1S/C49H57ClF3N7O6S2/c1-47(2,3)60-20-16-36(17-21-60)56-42-13-11-39(28-44(42)67(62,63)49(51,52)53)68(64,65)57-46(61)40-12-10-37(27-43(40)66-38-26-33-15-19-54-45(33)55-30-38)59-24-22-58(23-25-59)31-34-14-18-48(4,5)29-41(34)32-6-8-35(50)9-7-32/h6-13,15,19,26-28,30,36,56H,14,16-18,20-25,29,31H2,1-5H3,(H,54,55)(H,57,61)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	<-15.0	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC.; GENENTECH, INC.; THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH US Patent					Assay Description Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...				US Patent US9174982 (2015) BindingDB Entry DOI: 10.7270/Q2RB73D5
					More data for this Ligand-Target Pair