BDBM189696 US10213433, Compound 266::US9174982, 266

SMILES: CC(C)N1CCC2(CC1)CCC(=C(CN1CCN(CC1)c1ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c1)C2)c1ccc(Cl)cc1

InChI Key: InChIKey=ZUTXUNJIESJMER-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 189696   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189696 (US10213433, Compound 266 | US9174982, 266) Show SMILES CC(C)N1CCC2(CC1)CCC(=C(CN1CCN(CC1)c1ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c1)C2)c1ccc(Cl)cc1 |t:12| Show InChI InChI=1S/C50H59ClN8O7S/c1-34(2)57-19-16-50(17-20-57)15-11-43(36-3-5-39(51)6-4-36)38(30-50)33-56-21-23-58(24-22-56)40-7-9-44(47(28-40)66-41-27-37-12-18-52-48(37)54-32-41)49(60)55-67(63,64)42-8-10-45(46(29-42)59(61)62)53-31-35-13-25-65-26-14-35/h3-10,12,18,27-29,32,34-35,53H,11,13-17,19-26,30-31,33H2,1-2H3,(H,52,54)(H,55,60)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.				US Patent US10213433 (2019) BindingDB Entry DOI: 10.7270/Q23F4RZ6
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189696 (US10213433, Compound 266 | US9174982, 266) Show SMILES CC(C)N1CCC2(CC1)CCC(=C(CN1CCN(CC1)c1ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c1)C2)c1ccc(Cl)cc1 |t:12| Show InChI InChI=1S/C50H59ClN8O7S/c1-34(2)57-19-16-50(17-20-57)15-11-43(36-3-5-39(51)6-4-36)38(30-50)33-56-21-23-58(24-22-56)40-7-9-44(47(28-40)66-41-27-37-12-18-52-48(37)54-32-41)49(60)55-67(63,64)42-8-10-45(46(29-42)59(61)62)53-31-35-13-25-65-26-14-35/h3-10,12,18,27-29,32,34-35,53H,11,13-17,19-26,30-31,33H2,1-2H3,(H,52,54)(H,55,60)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	<-15.0	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC.; GENENTECH, INC.; THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH US Patent					Assay Description Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...				US Patent US9174982 (2015) BindingDB Entry DOI: 10.7270/Q2RB73D5
					More data for this Ligand-Target Pair