null

SMILES: FC1(COc2ncc(cc2Cl)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC4(CC4)CC3)c3ccc(Cl)cc3)CC2)CCN(CC1)C1COC1

InChI Key: InChIKey=FQAPGPHWDZHVOL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 189773   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189773 (US10213433, Compound 345 | US11369599, Compound 34...) Show SMILES FC1(COc2ncc(cc2Cl)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC4(CC4)CC3)c3ccc(Cl)cc3)CC2)CCN(CC1)C1COC1 |t:42| Show InChI InChI=1S/C47H50Cl2FN7O6S/c48-34-3-1-31(2-4-34)40-24-46(10-11-46)9-7-33(40)27-55-17-19-57(20-18-55)35-5-6-39(42(22-35)63-37-21-32-8-14-51-43(32)52-25-37)44(58)54-64(59,60)38-23-41(49)45(53-26-38)62-30-47(50)12-15-56(16-13-47)36-28-61-29-36/h1-6,8,14,21-23,25-26,36H,7,9-13,15-20,24,27-30H2,(H,51,52)(H,54,58)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	<-15.0	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC.; GENENTECH, INC.; THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH US Patent					Assay Description Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...				US Patent US9174982 (2015) BindingDB Entry DOI: 10.7270/Q2RB73D5
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189773 (US10213433, Compound 345 | US11369599, Compound 34...) Show SMILES FC1(COc2ncc(cc2Cl)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC4(CC4)CC3)c3ccc(Cl)cc3)CC2)CCN(CC1)C1COC1 |t:42| Show InChI InChI=1S/C47H50Cl2FN7O6S/c48-34-3-1-31(2-4-34)40-24-46(10-11-46)9-7-33(40)27-55-17-19-57(20-18-55)35-5-6-39(42(22-35)63-37-21-32-8-14-51-43(32)52-25-37)44(58)54-64(59,60)38-23-41(49)45(53-26-38)62-30-47(50)12-15-56(16-13-47)36-28-61-29-36/h1-6,8,14,21-23,25-26,36H,7,9-13,15-20,24,27-30H2,(H,51,52)(H,54,58)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189773 (US10213433, Compound 345 | US11369599, Compound 34...) Show SMILES FC1(COc2ncc(cc2Cl)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CCN(CC3=C(CC4(CC4)CC3)c3ccc(Cl)cc3)CC2)CCN(CC1)C1COC1 |t:42| Show InChI InChI=1S/C47H50Cl2FN7O6S/c48-34-3-1-31(2-4-34)40-24-46(10-11-46)9-7-33(40)27-55-17-19-57(20-18-55)35-5-6-39(42(22-35)63-37-21-32-8-14-51-43(32)52-25-37)44(58)54-64(59,60)38-23-41(49)45(53-26-38)62-30-47(50)12-15-56(16-13-47)36-28-61-29-36/h1-6,8,14,21-23,25-26,36H,7,9-13,15-20,24,27-30H2,(H,51,52)(H,54,58)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.				US Patent US10213433 (2019) BindingDB Entry DOI: 10.7270/Q23F4RZ6
					More data for this Ligand-Target Pair