null

SMILES: CN(C1CCCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1=CC(C)(C)NC(C)(C)C1

InChI Key: InChIKey=MLBGVPOJNQFCOJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190182   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM190182 (EPZ006089 | US9175331, 8) Show SMILES CN(C1CCCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1=CC(C)(C)NC(C)(C)C1 |t:30| Show InChI InChI=1S/C31H44N4O2/c1-19-13-20(2)33-29(37)26(19)18-32-28(36)25-14-22(23-16-30(4,5)34-31(6,7)17-23)15-27(21(25)3)35(8)24-11-9-10-12-24/h13-16,24,34H,9-12,17-18H2,1-8H3,(H,32,36)(H,33,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A687V] (Homo sapiens (Human))	BDBM190182 (EPZ006089 | US9175331, 8) Show SMILES CN(C1CCCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1=CC(C)(C)NC(C)(C)C1 |t:30| Show InChI InChI=1S/C31H44N4O2/c1-19-13-20(2)33-29(37)26(19)18-32-28(36)25-14-22(23-16-30(4,5)34-31(6,7)17-23)15-27(21(25)3)35(8)24-11-9-10-12-24/h13-16,24,34H,9-12,17-18H2,1-8H3,(H,32,36)(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.7	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A677G] (Homo sapiens (Human))	BDBM190182 (EPZ006089 | US9175331, 8) Show SMILES CN(C1CCCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1=CC(C)(C)NC(C)(C)C1 |t:30| Show InChI InChI=1S/C31H44N4O2/c1-19-13-20(2)33-29(37)26(19)18-32-28(36)25-14-22(23-16-30(4,5)34-31(6,7)17-23)15-27(21(25)3)35(8)24-11-9-10-12-24/h13-16,24,34H,9-12,17-18H2,1-8H3,(H,32,36)(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human))	BDBM190182 (EPZ006089 | US9175331, 8) Show SMILES CN(C1CCCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1=CC(C)(C)NC(C)(C)C1 |t:30| Show InChI InChI=1S/C31H44N4O2/c1-19-13-20(2)33-29(37)26(19)18-32-28(36)25-14-22(23-16-30(4,5)34-31(6,7)17-23)15-27(21(25)3)35(8)24-11-9-10-12-24/h13-16,24,34H,9-12,17-18H2,1-8H3,(H,32,36)(H,33,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	311	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair