null

SMILES: CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#C

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190188   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM190188 (EPZ007426 | US9175331, 15) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#C |r,wU:3.2,wD:6.9,(-5.33,3.47,;-5.33,1.93,;-4,1.15,;-4,-.38,;-2.67,-1.15,;-2.67,-2.69,;-4,-3.47,;-5.33,-2.69,;-5.33,-1.15,;-4,-5,;-2.67,-5.78,;-5.33,-5.78,;-2.67,1.93,;-2.67,3.47,;-1.33,4.23,;,3.47,;,1.93,;1.33,1.15,;2.67,1.93,;1.33,-.38,;2.67,-1.15,;2.67,-2.69,;4,-3.47,;5.33,-2.69,;4,-5,;2.67,-5.78,;2.67,-7.31,;1.33,-5,;1.33,-3.47,;,-2.69,;-1.33,1.15,;-1.33,-.38,;-1.33,5.78,;-1.33,7.31,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18.1	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A687V] (Homo sapiens (Human))	BDBM190188 (EPZ007426 | US9175331, 15) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#C |r,wU:3.2,wD:6.9,(-5.33,3.47,;-5.33,1.93,;-4,1.15,;-4,-.38,;-2.67,-1.15,;-2.67,-2.69,;-4,-3.47,;-5.33,-2.69,;-5.33,-1.15,;-4,-5,;-2.67,-5.78,;-5.33,-5.78,;-2.67,1.93,;-2.67,3.47,;-1.33,4.23,;,3.47,;,1.93,;1.33,1.15,;2.67,1.93,;1.33,-.38,;2.67,-1.15,;2.67,-2.69,;4,-3.47,;5.33,-2.69,;4,-5,;2.67,-5.78,;2.67,-7.31,;1.33,-5,;1.33,-3.47,;,-2.69,;-1.33,1.15,;-1.33,-.38,;-1.33,5.78,;-1.33,7.31,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A677G] (Homo sapiens (Human))	BDBM190188 (EPZ007426 | US9175331, 15) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#C |r,wU:3.2,wD:6.9,(-5.33,3.47,;-5.33,1.93,;-4,1.15,;-4,-.38,;-2.67,-1.15,;-2.67,-2.69,;-4,-3.47,;-5.33,-2.69,;-5.33,-1.15,;-4,-5,;-2.67,-5.78,;-5.33,-5.78,;-2.67,1.93,;-2.67,3.47,;-1.33,4.23,;,3.47,;,1.93,;1.33,1.15,;2.67,1.93,;1.33,-.38,;2.67,-1.15,;2.67,-2.69,;4,-3.47,;5.33,-2.69,;4,-5,;2.67,-5.78,;2.67,-7.31,;1.33,-5,;1.33,-3.47,;,-2.69,;-1.33,1.15,;-1.33,-.38,;-1.33,5.78,;-1.33,7.31,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human))	BDBM190188 (EPZ007426 | US9175331, 15) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#C |r,wU:3.2,wD:6.9,(-5.33,3.47,;-5.33,1.93,;-4,1.15,;-4,-.38,;-2.67,-1.15,;-2.67,-2.69,;-4,-3.47,;-5.33,-2.69,;-5.33,-1.15,;-4,-5,;-2.67,-5.78,;-5.33,-5.78,;-2.67,1.93,;-2.67,3.47,;-1.33,4.23,;,3.47,;,1.93,;1.33,1.15,;2.67,1.93,;1.33,-.38,;2.67,-1.15,;2.67,-2.69,;4,-3.47,;5.33,-2.69,;4,-5,;2.67,-5.78,;2.67,-7.31,;1.33,-5,;1.33,-3.47,;,-2.69,;-1.33,1.15,;-1.33,-.38,;-1.33,5.78,;-1.33,7.31,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair