null

SMILES: CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C(C)C

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190195   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM190195 (EPZ007790 | US9175331, 23) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C(C)C |r,wU:3.2,wD:6.9,(-5.33,3.85,;-5.33,2.31,;-4,1.54,;-4,,;-2.67,-.77,;-2.67,-2.31,;-4,-3.08,;-5.33,-2.31,;-5.33,-.77,;-4,-4.62,;-2.67,-5.39,;-5.33,-5.39,;-2.67,2.31,;-2.67,3.85,;-1.33,4.62,;,3.85,;,2.31,;1.33,1.54,;2.67,2.31,;1.33,,;2.67,-.77,;2.67,-2.31,;4,-3.08,;5.33,-2.31,;4,-4.62,;2.67,-5.39,;2.67,-6.93,;1.33,-4.62,;1.33,-3.08,;,-2.31,;-1.33,1.54,;-1.33,,;-1.33,6.16,;-2.67,6.93,;,6.93,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16.9	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A687V] (Homo sapiens (Human))	BDBM190195 (EPZ007790 | US9175331, 23) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C(C)C |r,wU:3.2,wD:6.9,(-5.33,3.85,;-5.33,2.31,;-4,1.54,;-4,,;-2.67,-.77,;-2.67,-2.31,;-4,-3.08,;-5.33,-2.31,;-5.33,-.77,;-4,-4.62,;-2.67,-5.39,;-5.33,-5.39,;-2.67,2.31,;-2.67,3.85,;-1.33,4.62,;,3.85,;,2.31,;1.33,1.54,;2.67,2.31,;1.33,,;2.67,-.77,;2.67,-2.31,;4,-3.08,;5.33,-2.31,;4,-4.62,;2.67,-5.39,;2.67,-6.93,;1.33,-4.62,;1.33,-3.08,;,-2.31,;-1.33,1.54,;-1.33,,;-1.33,6.16,;-2.67,6.93,;,6.93,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A677G] (Homo sapiens (Human))	BDBM190195 (EPZ007790 | US9175331, 23) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C(C)C |r,wU:3.2,wD:6.9,(-5.33,3.85,;-5.33,2.31,;-4,1.54,;-4,,;-2.67,-.77,;-2.67,-2.31,;-4,-3.08,;-5.33,-2.31,;-5.33,-.77,;-4,-4.62,;-2.67,-5.39,;-5.33,-5.39,;-2.67,2.31,;-2.67,3.85,;-1.33,4.62,;,3.85,;,2.31,;1.33,1.54,;2.67,2.31,;1.33,,;2.67,-.77,;2.67,-2.31,;4,-3.08,;5.33,-2.31,;4,-4.62,;2.67,-5.39,;2.67,-6.93,;1.33,-4.62,;1.33,-3.08,;,-2.31,;-1.33,1.54,;-1.33,,;-1.33,6.16,;-2.67,6.93,;,6.93,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human))	BDBM190195 (EPZ007790 | US9175331, 23) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C(C)C |r,wU:3.2,wD:6.9,(-5.33,3.85,;-5.33,2.31,;-4,1.54,;-4,,;-2.67,-.77,;-2.67,-2.31,;-4,-3.08,;-5.33,-2.31,;-5.33,-.77,;-4,-4.62,;-2.67,-5.39,;-5.33,-5.39,;-2.67,2.31,;-2.67,3.85,;-1.33,4.62,;,3.85,;,2.31,;1.33,1.54,;2.67,2.31,;1.33,,;2.67,-.77,;2.67,-2.31,;4,-3.08,;5.33,-2.31,;4,-4.62,;2.67,-5.39,;2.67,-6.93,;1.33,-4.62,;1.33,-3.08,;,-2.31,;-1.33,1.54,;-1.33,,;-1.33,6.16,;-2.67,6.93,;,6.93,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.8	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair