BDBM190204 EPZ008491::US9175331, 35

SMILES: CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C(=O)N1CCC1

InChI Key:

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190204   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM190204 (EPZ008491 | US9175331, 35) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C(=O)N1CCC1 |r,wU:3.2,wD:6.9,(2.67,4.23,;1.33,5,;,4.23,;-1.33,5,;-2.67,4.23,;-4,5,;-4,6.54,;-2.67,7.31,;-1.33,6.54,;-5.33,7.31,;-6.67,6.54,;-5.33,8.85,;,2.69,;-1.33,1.93,;-1.33,.38,;,-.38,;1.33,.38,;2.67,-.38,;4,.38,;2.67,-1.93,;4,-2.69,;4,-4.23,;5.33,-5,;6.67,-4.23,;5.33,-6.54,;4,-7.31,;4,-8.85,;2.67,-6.54,;2.67,-5,;1.33,-4.23,;1.33,1.93,;2.67,2.69,;-2.67,-.38,;-4,.38,;-2.67,-1.93,;-3.76,-3.01,;-2.67,-4.1,;-1.58,-3.01,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (A687V) (Homo sapiens (Human))	BDBM190204 (EPZ008491 | US9175331, 35) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C(=O)N1CCC1 |r,wU:3.2,wD:6.9,(2.67,4.23,;1.33,5,;,4.23,;-1.33,5,;-2.67,4.23,;-4,5,;-4,6.54,;-2.67,7.31,;-1.33,6.54,;-5.33,7.31,;-6.67,6.54,;-5.33,8.85,;,2.69,;-1.33,1.93,;-1.33,.38,;,-.38,;1.33,.38,;2.67,-.38,;4,.38,;2.67,-1.93,;4,-2.69,;4,-4.23,;5.33,-5,;6.67,-4.23,;5.33,-6.54,;4,-7.31,;4,-8.85,;2.67,-6.54,;2.67,-5,;1.33,-4.23,;1.33,1.93,;2.67,2.69,;-2.67,-.38,;-4,.38,;-2.67,-1.93,;-3.76,-3.01,;-2.67,-4.1,;-1.58,-3.01,)| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (A677G) (Homo sapiens (Human))	BDBM190204 (EPZ008491 | US9175331, 35) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C(=O)N1CCC1 |r,wU:3.2,wD:6.9,(2.67,4.23,;1.33,5,;,4.23,;-1.33,5,;-2.67,4.23,;-4,5,;-4,6.54,;-2.67,7.31,;-1.33,6.54,;-5.33,7.31,;-6.67,6.54,;-5.33,8.85,;,2.69,;-1.33,1.93,;-1.33,.38,;,-.38,;1.33,.38,;2.67,-.38,;4,.38,;2.67,-1.93,;4,-2.69,;4,-4.23,;5.33,-5,;6.67,-4.23,;5.33,-6.54,;4,-7.31,;4,-8.85,;2.67,-6.54,;2.67,-5,;1.33,-4.23,;1.33,1.93,;2.67,2.69,;-2.67,-.38,;-4,.38,;-2.67,-1.93,;-3.76,-3.01,;-2.67,-4.1,;-1.58,-3.01,)| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
EZH2(Y641F) (Homo sapiens (Human))	BDBM190204 (EPZ008491 | US9175331, 35) Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C(=O)N1CCC1 |r,wU:3.2,wD:6.9,(2.67,4.23,;1.33,5,;,4.23,;-1.33,5,;-2.67,4.23,;-4,5,;-4,6.54,;-2.67,7.31,;-1.33,6.54,;-5.33,7.31,;-6.67,6.54,;-5.33,8.85,;,2.69,;-1.33,1.93,;-1.33,.38,;,-.38,;1.33,.38,;2.67,-.38,;4,.38,;2.67,-1.93,;4,-2.69,;4,-4.23,;5.33,-5,;6.67,-4.23,;5.33,-6.54,;4,-7.31,;4,-8.85,;2.67,-6.54,;2.67,-5,;1.33,-4.23,;1.33,1.93,;2.67,2.69,;-2.67,-.38,;-4,.38,;-2.67,-1.93,;-3.76,-3.01,;-2.67,-4.1,;-1.58,-3.01,)| Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair