null

SMILES: CCN(C1CCC(CC1)C(C)C)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C

InChI Key: InChIKey=NZONDTYRDVXWID-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190215   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM190215 (EPZ009090 | US9175331, 51) Show SMILES CCN(C1CCC(CC1)C(C)C)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |(-5.33,4.23,;-5.33,2.69,;-4,1.93,;-4,.38,;-5.33,-.38,;-5.33,-1.93,;-4,-2.69,;-2.67,-1.93,;-2.67,-.38,;-4,-4.23,;-5.33,-5,;-2.67,-5,;-2.67,2.69,;-2.67,4.23,;-1.33,5,;-1.33,6.54,;,4.23,;,2.69,;1.33,1.93,;2.67,2.69,;1.33,.38,;2.67,-.38,;2.67,-1.93,;4,-2.69,;5.33,-1.93,;4,-4.23,;2.67,-5,;2.67,-6.54,;1.33,-4.23,;1.33,-2.69,;,-1.93,;-1.33,1.93,;-1.33,.38,)| Show InChI InChI=1S/C27H38ClN3O2/c1-7-31(22-10-8-20(9-11-22)16(2)3)25-14-21(28)13-23(19(25)6)26(32)29-15-24-17(4)12-18(5)30-27(24)33/h12-14,16,20,22H,7-11,15H2,1-6H3,(H,29,32)(H,30,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A687V] (Homo sapiens (Human))	BDBM190215 (EPZ009090 | US9175331, 51) Show SMILES CCN(C1CCC(CC1)C(C)C)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |(-5.33,4.23,;-5.33,2.69,;-4,1.93,;-4,.38,;-5.33,-.38,;-5.33,-1.93,;-4,-2.69,;-2.67,-1.93,;-2.67,-.38,;-4,-4.23,;-5.33,-5,;-2.67,-5,;-2.67,2.69,;-2.67,4.23,;-1.33,5,;-1.33,6.54,;,4.23,;,2.69,;1.33,1.93,;2.67,2.69,;1.33,.38,;2.67,-.38,;2.67,-1.93,;4,-2.69,;5.33,-1.93,;4,-4.23,;2.67,-5,;2.67,-6.54,;1.33,-4.23,;1.33,-2.69,;,-1.93,;-1.33,1.93,;-1.33,.38,)| Show InChI InChI=1S/C27H38ClN3O2/c1-7-31(22-10-8-20(9-11-22)16(2)3)25-14-21(28)13-23(19(25)6)26(32)29-15-24-17(4)12-18(5)30-27(24)33/h12-14,16,20,22H,7-11,15H2,1-6H3,(H,29,32)(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22.7	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A677G] (Homo sapiens (Human))	BDBM190215 (EPZ009090 | US9175331, 51) Show SMILES CCN(C1CCC(CC1)C(C)C)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |(-5.33,4.23,;-5.33,2.69,;-4,1.93,;-4,.38,;-5.33,-.38,;-5.33,-1.93,;-4,-2.69,;-2.67,-1.93,;-2.67,-.38,;-4,-4.23,;-5.33,-5,;-2.67,-5,;-2.67,2.69,;-2.67,4.23,;-1.33,5,;-1.33,6.54,;,4.23,;,2.69,;1.33,1.93,;2.67,2.69,;1.33,.38,;2.67,-.38,;2.67,-1.93,;4,-2.69,;5.33,-1.93,;4,-4.23,;2.67,-5,;2.67,-6.54,;1.33,-4.23,;1.33,-2.69,;,-1.93,;-1.33,1.93,;-1.33,.38,)| Show InChI InChI=1S/C27H38ClN3O2/c1-7-31(22-10-8-20(9-11-22)16(2)3)25-14-21(28)13-23(19(25)6)26(32)29-15-24-17(4)12-18(5)30-27(24)33/h12-14,16,20,22H,7-11,15H2,1-6H3,(H,29,32)(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human))	BDBM190215 (EPZ009090 | US9175331, 51) Show SMILES CCN(C1CCC(CC1)C(C)C)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |(-5.33,4.23,;-5.33,2.69,;-4,1.93,;-4,.38,;-5.33,-.38,;-5.33,-1.93,;-4,-2.69,;-2.67,-1.93,;-2.67,-.38,;-4,-4.23,;-5.33,-5,;-2.67,-5,;-2.67,2.69,;-2.67,4.23,;-1.33,5,;-1.33,6.54,;,4.23,;,2.69,;1.33,1.93,;2.67,2.69,;1.33,.38,;2.67,-.38,;2.67,-1.93,;4,-2.69,;5.33,-1.93,;4,-4.23,;2.67,-5,;2.67,-6.54,;1.33,-4.23,;1.33,-2.69,;,-1.93,;-1.33,1.93,;-1.33,.38,)| Show InChI InChI=1S/C27H38ClN3O2/c1-7-31(22-10-8-20(9-11-22)16(2)3)25-14-21(28)13-23(19(25)6)26(32)29-15-24-17(4)12-18(5)30-27(24)33/h12-14,16,20,22H,7-11,15H2,1-6H3,(H,29,32)(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.1	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair