BDBM190853 US9670203, Compound 1.70 1-(3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl)-3-((1S,1aS,6bS)-5-((7-oxo-5,6,7, 8-tetrahydro-1,8-naphthyridin-4-yl)oxy)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-1-yl)urea

SMILES: CC(C)(N)c1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(c1)C(F)(F)F

InChI Key: InChIKey=CFJBNDJOJOJNMA-HJOGWXRNSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 190853   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-Raf (Y340D/Y341D) (Homo sapiens (Human))	BDBM190853 (US9670203, Compound 1.70 1-(3-(2-aminopropan-2-yl)...) Show SMILES CC(C)(N)c1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C28H26F3N5O4/c1-27(2,32)13-9-14(28(29,30)31)11-15(10-13)34-26(38)36-23-22-18-12-16(3-5-19(18)40-24(22)23)39-20-7-8-33-25-17(20)4-6-21(37)35-25/h3,5,7-12,22-24H,4,6,32H2,1-2H3,(H,33,35,37)(H2,34,36,38)/t22-,23-,24-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair
B-Raf (V600E) (Homo sapiens (Human))	BDBM190853 (US9670203, Compound 1.70 1-(3-(2-aminopropan-2-yl)...) Show SMILES CC(C)(N)c1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C28H26F3N5O4/c1-27(2,32)13-9-14(28(29,30)31)11-15(10-13)34-26(38)36-23-22-18-12-16(3-5-19(18)40-24(22)23)39-20-7-8-33-25-17(20)4-6-21(37)35-25/h3,5,7-12,22-24H,4,6,32H2,1-2H3,(H,33,35,37)(H2,34,36,38)/t22-,23-,24-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair