null

SMILES: CCN1CCN(Cc2ccc(NC(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7NC(=O)CCc67)cc5[C@@H]34)cc2C(F)(F)F)CC1

InChI Key: InChIKey=ZRUPBLAJHMUPHL-AWCRTANDSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 190870   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] (Homo sapiens (Human))	BDBM190870 (US9670203, Compound 1.73 1-(4-((4-ethylpiperazin-1...) Show SMILES CCN1CCN(Cc2ccc(NC(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7NC(=O)CCc67)cc5[C@@H]34)cc2C(F)(F)F)CC1 |r| Show InChI InChI=1S/C32H33F3N6O4/c1-2-40-11-13-41(14-12-40)17-18-3-4-19(15-23(18)32(33,34)35)37-31(43)39-28-27-22-16-20(5-7-24(22)45-29(27)28)44-25-9-10-36-30-21(25)6-8-26(42)38-30/h3-5,7,9-10,15-16,27-29H,2,6,8,11-14,17H2,1H3,(H,36,38,42)(H2,37,39,43)/t27-,28-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [416-766,V600E] (Homo sapiens (Human))	BDBM190870 (US9670203, Compound 1.73 1-(4-((4-ethylpiperazin-1...) Show SMILES CCN1CCN(Cc2ccc(NC(=O)N[C@@H]3[C@H]4Oc5ccc(Oc6ccnc7NC(=O)CCc67)cc5[C@@H]34)cc2C(F)(F)F)CC1 |r| Show InChI InChI=1S/C32H33F3N6O4/c1-2-40-11-13-41(14-12-40)17-18-3-4-19(15-23(18)32(33,34)35)37-31(43)39-28-27-22-16-20(5-7-24(22)45-29(27)28)44-25-9-10-36-30-21(25)6-8-26(42)38-30/h3-5,7,9-10,15-16,27-29H,2,6,8,11-14,17H2,1H3,(H,36,38,42)(H2,37,39,43)/t27-,28-,29-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair