BDBM191138 US9181261, 15

SMILES: CC(C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1cnc(nc1)C(C)(C)C

InChI Key: InChIKey=JFQSTEIZOLGXFO-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 191138   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191138 (US9181261, 15) Show SMILES CC(C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1cnc(nc1)C(C)(C)C Show InChI InChI=1S/C22H27N5OS/c1-15(2)27(14-16-7-6-8-17(11-16)19-23-9-10-29-19)21(28)26-18-12-24-20(25-13-18)22(3,4)5/h6-13,15H,14H2,1-5H3,(H,26,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	102	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair