BDBM191345 US9670203, Compound 2.8

SMILES: CNC(=O)c1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5cc(F)c(F)cc5F)[C@@H]4c3c2)ccn1

InChI Key: InChIKey=FPGVPWSNALFMJP-ACRUOGEOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 191345   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-Raf (Y340D/Y341D) (Homo sapiens (Human))	BDBM191345 (US9670203, Compound 2.8) Show SMILES CNC(=O)c1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5cc(F)c(F)cc5F)[C@@H]4c3c2)ccn1 |r| Show InChI InChI=1S/C23H17F3N4O4/c1-27-22(31)17-7-11(4-5-28-17)33-10-2-3-18-12(6-10)19-20(21(19)34-18)30-23(32)29-16-9-14(25)13(24)8-15(16)26/h2-9,19-21H,1H3,(H,27,31)(H2,29,30,32)/t19-,20-,21-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair
B-Raf (V600E) (Homo sapiens (Human))	BDBM191345 (US9670203, Compound 2.8) Show SMILES CNC(=O)c1cc(Oc2ccc3O[C@@H]4[C@@H](NC(=O)Nc5cc(F)c(F)cc5F)[C@@H]4c3c2)ccn1 |r| Show InChI InChI=1S/C23H17F3N4O4/c1-27-22(31)17-7-11(4-5-28-17)33-10-2-3-18-12(6-10)19-20(21(19)34-18)30-23(32)29-16-9-14(25)13(24)8-15(16)26/h2-9,19-21H,1H3,(H,27,31)(H2,29,30,32)/t19-,20-,21-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	25
BeiGene, Ltd. US Patent					Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...				US Patent US9670203 (2017) BindingDB Entry DOI: 10.7270/Q20Z71F5
					More data for this Ligand-Target Pair