null
SMILES: CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C(C#N)C(N)=O)cc3)nc12
InChI Key: InChIKey=RPBXLJQRICEDDS-MDWZMJQESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK3 [781-1124] (Homo sapiens (Human)) | BDBM192802 (US9187487, 60) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.5 | -248.15 |
PRINCIPIA BIOPHARMA, INC. US Patent | Assay Description Phosphorylation of the appropriate peptide substrate (fluorescently labeled Srctide) by recombinant JAK3 (catalytic domain, aa 781-1124) was measured... | US Patent US9187487 (2015) BindingDB Entry DOI: 10.7270/Q2K936B3 | |||||||||||
More data for this Ligand-Target Pair |