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SMILES: CN1CCN(Cc2ccc(cc2)-c2cc3ccc(F)cc3c(=O)[nH]2)CC1

InChI Key: InChIKey=RHEFZETXUVPJQF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 192898   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Poly [ADP-ribose] polymerase tankyrase-1 [1068-1325]


(Homo sapiens (Human))		BDBM192898
PNG
(US9193689, REF-2)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cc3ccc(F)cc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C21H22FN3O/c1-24-8-10-25(11-9-24)14-15-2-4-16(5-3-15)20-12-17-6-7-18(22)13-19(17)21(26)23-20/h2-7,12-13H,8-11,14H2,1H3,(H,23,26)
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Similars
US Patent
n/an/a 48n/an/an/an/an/an/a



INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
Tankyrase activity was assayed using a 96-well format HT Universal Chemiluminescent PARP Assay Kit (Trevigen, Inc, cat. no. 4676-096-K) according to ...

US Patent US9193689 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PTR
More data for this
Ligand-Target Pair