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SMILES: CN1CCN(CC1)C(=O)c1ccc(cn1)-c1cc2c(C)cc(F)cc2c(=O)[nH]1

InChI Key: InChIKey=UUJUREMRXOHERG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 192909   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Poly [ADP-ribose] polymerase tankyrase-1 [1068-1325]


(Homo sapiens (Human))		BDBM192909
PNG
(US9193689, IQ-222)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cn1)-c1cc2c(C)cc(F)cc2c(=O)[nH]1
Show InChI InChI=1S/C21H21FN4O2/c1-13-9-15(22)10-17-16(13)11-19(24-20(17)27)14-3-4-18(23-12-14)21(28)26-7-5-25(2)6-8-26/h3-4,9-12H,5-8H2,1-2H3,(H,24,27)
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Similars
US Patent
n/an/a 16n/an/an/an/an/an/a



INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
Tankyrase activity was assayed using a 96-well format HT Universal Chemiluminescent PARP Assay Kit (Trevigen, Inc, cat. no. 4676-096-K) according to ...

US Patent US9193689 (2015)


BindingDB Entry DOI: 10.7270/Q29S1PTR
More data for this
Ligand-Target Pair