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SMILES: Cc1ccc(cc1NC(=O)c1cnc2ccc(cn12)-c1cnn(CC(C)(C)O)c1)-c1noc(n1)C1CC(F)(F)C1

InChI Key: InChIKey=LSWXHHBJJIGZTD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193953   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM193953
PNG
(US9199981, F44)
Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccc(cn12)-c1cnn(CC(C)(C)O)c1)-c1noc(n1)C1CC(F)(F)C1
Show InChI InChI=1S/C28H27F2N7O3/c1-16-4-5-17(24-34-26(40-35-24)19-9-28(29,30)10-19)8-21(16)33-25(38)22-12-31-23-7-6-18(14-37(22)23)20-11-32-36(13-20)15-27(2,3)39/h4-8,11-14,19,39H,9-10,15H2,1-3H3,(H,33,38)
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Similars
US Patent
n/an/a 6n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...

US Patent US9199981 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TKJ
More data for this
Ligand-Target Pair