BDBM193968 US9199981, F59

SMILES: Cc1ccc(cc1NC(=O)c1cnc2cc(ccn12)N1CCOCC1)-c1noc(n1)C1CC(F)(F)C1

InChI Key: InChIKey=QDBQXAHDNLLVQI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193968   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM193968 (US9199981, F59) Show SMILES Cc1ccc(cc1NC(=O)c1cnc2cc(ccn12)N1CCOCC1)-c1noc(n1)C1CC(F)(F)C1 Show InChI InChI=1S/C25H24F2N6O3/c1-15-2-3-16(22-30-24(36-31-22)17-12-25(26,27)13-17)10-19(15)29-23(34)20-14-28-21-11-18(4-5-33(20)21)32-6-8-35-9-7-32/h2-5,10-11,14,17H,6-9,12-13H2,1H3,(H,29,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...				US Patent US9199981 (2015) BindingDB Entry DOI: 10.7270/Q2M32TKJ
					More data for this Ligand-Target Pair