null

SMILES: CCc1ncc(Cc2ccc3cccc(CNS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=CMSFJDOPWNGHLE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 194412   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194412 (US9200016, 94 | US9902710, Compound 94) Show SMILES CCc1ncc(Cc2ccc3cccc(CNS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H26N4O4S/c1-4-21-20-12-23(32-3)22(31-2)11-19(20)17(13-26-21)10-18-9-8-15-6-5-7-16(24(15)28-18)14-27-33(25,29)30/h5-9,11-13,27H,4,10,14H2,1-3H3,(H2,25,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194412 (US9200016, 94 | US9902710, Compound 94) Show SMILES CCc1ncc(Cc2ccc3cccc(CNS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H26N4O4S/c1-4-21-20-12-23(32-3)22(31-2)11-19(20)17(13-26-21)10-18-9-8-15-6-5-7-16(24(15)28-18)14-27-33(25,29)30/h5-9,11-13,27H,4,10,14H2,1-3H3,(H2,25,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	37
Allergan, Inc.; Exonhit Therapeutics, SA US Patent					Assay Description The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....				US Patent US9200016 (2015) BindingDB Entry DOI: 10.7270/Q2ZC81PH
					More data for this Ligand-Target Pair