null

SMILES: CCCc1ncc(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=CTRRBGCRWMWSBT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 194447   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194447 (US9200016, 129 | US9902710, Compound 129) Show SMILES CCCc1ncc(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H29N3O3/c1-6-7-23-21-14-25(32-5)24(31-4)13-20(21)18(15-28-23)11-17-10-16-12-19(30-3)8-9-22(16)29-26(17)27-2/h8-10,12-15H,6-7,11H2,1-5H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194447 (US9200016, 129 | US9902710, Compound 129) Show SMILES CCCc1ncc(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H29N3O3/c1-6-7-23-21-14-25(32-5)24(31-4)13-20(21)18(15-28-23)11-17-10-16-12-19(30-3)8-9-22(16)29-26(17)27-2/h8-10,12-15H,6-7,11H2,1-5H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.5	n/a	n/a	n/a	n/a	7.4	37
Allergan, Inc.; Exonhit Therapeutics, SA US Patent					Assay Description The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....				US Patent US9200016 (2015) BindingDB Entry DOI: 10.7270/Q2ZC81PH
					More data for this Ligand-Target Pair