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SMILES: COc1cc2c(C)ncc(Cc3ccc4cccc(NS(N)(=O)=O)c4n3)c2cc1OC

InChI Key: InChIKey=ZKTNDXQPFBNCJY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 194474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194474 (US9200016, 156 | US9902710, Compound 156) Show SMILES COc1cc2c(C)ncc(Cc3ccc4cccc(NS(N)(=O)=O)c4n3)c2cc1OC Show InChI InChI=1S/C22H22N4O4S/c1-13-17-10-20(29-2)21(30-3)11-18(17)15(12-24-13)9-16-8-7-14-5-4-6-19(22(14)25-16)26-31(23,27)28/h4-8,10-12,26H,9H2,1-3H3,(H2,23,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.710	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194474 (US9200016, 156 | US9902710, Compound 156) Show SMILES COc1cc2c(C)ncc(Cc3ccc4cccc(NS(N)(=O)=O)c4n3)c2cc1OC Show InChI InChI=1S/C22H22N4O4S/c1-13-17-10-20(29-2)21(30-3)11-18(17)15(12-24-13)9-16-8-7-14-5-4-6-19(22(14)25-16)26-31(23,27)28/h4-8,10-12,26H,9H2,1-3H3,(H2,23,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.710	n/a	n/a	n/a	n/a	7.4	37
Allergan, Inc.; Exonhit Therapeutics, SA US Patent					Assay Description The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....				US Patent US9200016 (2015) BindingDB Entry DOI: 10.7270/Q2ZC81PH
					More data for this Ligand-Target Pair