BDBM194487 US9200016, 169::US9902710, Compound 169

SMILES: COCc1ncc(Cc2cnc3ccc(O)c(c3c2)C(F)(F)F)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=AQCSZBJZPWCJBX-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 194487   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM194487 (US9200016, 169 | US9902710, Compound 169) Show SMILES COCc1ncc(Cc2cnc3ccc(O)c(c3c2)C(F)(F)F)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H21F3N2O4/c1-31-12-19-16-9-22(33-3)21(32-2)8-15(16)14(11-29-19)6-13-7-17-18(28-10-13)4-5-20(30)23(17)24(25,26)27/h4-5,7-11,30H,6,12H2,1-3H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	194	n/a	n/a	n/a	n/a	7.4	37
Allergan, Inc.; Exonhit Therapeutics, SA US Patent					Assay Description The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....				US Patent US9200016 (2015) BindingDB Entry DOI: 10.7270/Q2ZC81PH
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM194487 (US9200016, 169 | US9902710, Compound 169) Show SMILES COCc1ncc(Cc2cnc3ccc(O)c(c3c2)C(F)(F)F)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H21F3N2O4/c1-31-12-19-16-9-22(33-3)21(32-2)8-15(16)14(11-29-19)6-13-7-17-18(28-10-13)4-5-20(30)23(17)24(25,26)27/h4-5,7-11,30H,6,12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194487 (US9200016, 169 | US9902710, Compound 169) Show SMILES COCc1ncc(Cc2cnc3ccc(O)c(c3c2)C(F)(F)F)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H21F3N2O4/c1-31-12-19-16-9-22(33-3)21(32-2)8-15(16)14(11-29-19)6-13-7-17-18(28-10-13)4-5-20(30)23(17)24(25,26)27/h4-5,7-11,30H,6,12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	7.4	37
Allergan, Inc.; Exonhit Therapeutics, SA US Patent					Assay Description The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....				US Patent US9200016 (2015) BindingDB Entry DOI: 10.7270/Q2ZC81PH
					More data for this Ligand-Target Pair