BDBM195901 US9206188, 133::US9834551, Example 133
SMILES: COc1c(F)cc(F)cc1-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)\C=C\CN(C)C)ccc1F
InChI Key: InChIKey=NASHROIQYXOKDD-SNAWJCMRSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM195901 (US9206188, 133 | US9834551, Example 133) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
ARRIEN PHARMACEUTICALS LLC US Patent | Assay Description 1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja... | US Patent US9206188 (2015) BindingDB Entry DOI: 10.7270/Q2057DRT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM195901 (US9206188, 133 | US9834551, Example 133) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARRIEN PHARMACEUTICALS LLC US Patent | Assay Description 1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja... | US Patent US9206188 (2015) BindingDB Entry DOI: 10.7270/Q2057DRT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM195901 (US9206188, 133 | US9834551, Example 133) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 72.4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARRIEN PHARMACEUTICALS LLC US Patent | Assay Description 1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja... | US Patent US9206188 (2015) BindingDB Entry DOI: 10.7270/Q2057DRT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM195901 (US9206188, 133 | US9834551, Example 133) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
ARRIEN PHARMACEUTICALS LLC US Patent | Assay Description ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ... | US Patent US9834551 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5C4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM195901 (US9206188, 133 | US9834551, Example 133) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
ARRIEN PHARMACEUTICALS LLC US Patent | Assay Description 1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja... | US Patent US9206188 (2015) BindingDB Entry DOI: 10.7270/Q2057DRT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM195901 (US9206188, 133 | US9834551, Example 133) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
ARRIEN PHARMACEUTICALS LLC US Patent | Assay Description ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ... | US Patent US9834551 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5C4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM195901 (US9206188, 133 | US9834551, Example 133) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ARRIEN PHARMACEUTICALS LLC US Patent | Assay Description 1H-pyrrolo[2,3-b]pyridine, 1H-pyrazolo[3,4-b]pyridine and 5H-pyrrolo[2,3-b]pyrazine series of compounds exhibited over >100 fold selective against Ja... | US Patent US9206188 (2015) BindingDB Entry DOI: 10.7270/Q2057DRT | |||||||||||
More data for this Ligand-Target Pair |