BDBM196528 US9212165, 71

SMILES: O=C(NC12CC3CC(C1)CC(C3)(C2)C#Cc1ccccn1)c1cnccn1

InChI Key: InChIKey=VGUIQEVHYUUIPY-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 196528   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM196528 (US9212165, 71) Show SMILES O=C(NC12CC3CC(C1)CC(C3)(C2)C#Cc1ccccn1)c1cnccn1 |TLB:2:3:6:9.10.11,13:10:6:3.4.8,THB:4:3:9:6.5.11,4:5:9:3.12.8,12:3:6:9.10.11,12:10:6:3.4.8| Show InChI InChI=1S/C22H22N4O/c27-20(19-14-23-7-8-25-19)26-22-12-16-9-17(13-22)11-21(10-16,15-22)5-4-18-3-1-2-6-24-18/h1-3,6-8,14,16-17H,9-13,15H2,(H,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.70	-11.4	n/a	n/a	n/a	n/a	n/a	7.4	25
H. Lundbeck A/S US Patent					Assay Description Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...				US Patent US9212165 (2015) BindingDB Entry DOI: 10.7270/Q2Z89B69
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