BDBM196692 US9212171, 17

SMILES: CN1C(=O)C(CCC1(C)C)c1ncc(cn1)C#Cc1cccc(F)c1

InChI Key: InChIKey=QXBULACCZLWSRJ-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 196692   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5a (mGluR5) (Homo sapiens (Human))	BDBM196692 (US9212171, 17) Show SMILES CN1C(=O)C(CCC1(C)C)c1ncc(cn1)C#Cc1cccc(F)c1 Show InChI InChI=1S/C20H20FN3O/c1-20(2)10-9-17(19(25)24(20)3)18-22-12-15(13-23-18)8-7-14-5-4-6-16(21)11-14/h4-6,11-13,17H,9-10H2,1-3H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	132	n/a	n/a	n/a	37
HOFFMANN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9212171 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TWH
					More data for this Ligand-Target Pair