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SMILES: CNc1nc(Nc2cn(nc2C)C(C)(C)c2nc(C)cn2C)ncc1C(F)(F)F

InChI Key: InChIKey=JGUMXBZMRBCEIE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 196738   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196738
PNG
(US9212173, 16)
Show SMILES CNc1nc(Nc2cn(nc2C)C(C)(C)c2nc(C)cn2C)ncc1C(F)(F)F
Show InChI InChI=1S/C18H23F3N8/c1-10-8-28(6)15(24-10)17(3,4)29-9-13(11(2)27-29)25-16-23-7-12(18(19,20)21)14(22-5)26-16/h7-9H,1-6H3,(H2,22,23,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
 140n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212173 (2015)


BindingDB Entry DOI: 10.7270/Q2222SKT
More data for this
Ligand-Target Pair