BindingDB logo
myBDB logout

null

SMILES: CNc1nc(Nc2cn(nc2C)C(C)(C)c2ncccn2)ncc1C(F)(F)F

InChI Key: InChIKey=WSUTVOQKARPJBC-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 196748   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196748
PNG
(US9212173, 26)
Show SMILES CNc1nc(Nc2cn(nc2C)C(C)(C)c2ncccn2)ncc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N8/c1-10-12(9-28(27-10)16(2,3)14-22-6-5-7-23-14)25-15-24-8-11(17(18,19)20)13(21-4)26-15/h5-9H,1-4H3,(H2,21,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 4.30n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212173 (2015)


BindingDB Entry DOI: 10.7270/Q2222SKT
More data for this
Ligand-Target Pair