BDBM196749 US9212173, 27

SMILES: CCNc1nc(Nc2cn(nc2Cl)C(C)(C)c2nnc(C)o2)ncc1C(F)(F)F

InChI Key: InChIKey=SJXXOPHKNUAQNN-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 196749   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM196749 (US9212173, 27) Show SMILES CCNc1nc(Nc2cn(nc2Cl)C(C)(C)c2nnc(C)o2)ncc1C(F)(F)F Show InChI InChI=1S/C16H18ClF3N8O/c1-5-21-12-9(16(18,19)20)6-22-14(24-12)23-10-7-28(27-11(10)17)15(3,4)13-26-25-8(2)29-13/h6-7H,5H2,1-4H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...				US Patent US9212173 (2015) BindingDB Entry DOI: 10.7270/Q2222SKT
					More data for this Ligand-Target Pair