BindingDB logo
myBDB logout

null

SMILES: Cc1nn(cc1Nc1ncc(C#N)c(NC2CC2)n1)C(C)(C)C#N

InChI Key: InChIKey=OGRWMPLKIGSOBK-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 196767   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196767
PNG
(US9212173, 46)
Show SMILES Cc1nn(cc1Nc1ncc(C#N)c(NC2CC2)n1)C(C)(C)C#N
Show InChI InChI=1S/C16H18N8/c1-10-13(8-24(23-10)16(2,3)9-18)21-15-19-7-11(6-17)14(22-15)20-12-4-5-12/h7-8,12H,4-5H2,1-3H3,(H2,19,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212173 (2015)


BindingDB Entry DOI: 10.7270/Q2222SKT
More data for this
Ligand-Target Pair